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PROFÁRMACO DE AMINOÁCIDO CONTENDO FLÚOR
专利权人:
LTD.;TAISHO PHARMACEUTICAL CO.
发明人:
KAZUNARI SAKAGAMI,TAKASHI HASHIHAYATA,NORIKAZU OTAKE,NAOKI MIYAKOSHI
申请号:
PT13797352
公开号:
PT2857385T
申请日:
2013.05.31
申请国别(地区):
PT
年份:
2017
代理人:
摘要:
Provided are a fluorine-containing amino acid prodrug represented by general formula (I) that makes a fluorine-containing amino acid which is a group 2 metabotropic glutamate receptor agonist into a prodrug, or a pharmaceutically acceptable salt thereof. More specifically, provided is a prodrug that increases the in vivo exposure and enhances the oral absorbability and other mucosal absorbability of a parent compound that acts on group 2 metabotropic glutamate receptors as an agent for the treatment or prevention of diseases in which group 2 metabotropic glutamate receptors are said to be involved, such as: schizophrenia, anxiety disorder and its related diseases, depression, bipolar disorder, epilepsy, developmental disorders, sleep disorders, and other neuropsychiatric diseases; and drug dependence, cognitive disorders, Alzheimer's disease, Huntington's chorea, Parkinson's disease, movement disorders associated with muscular rigidity, cerebral ischemia, cerebral insufficiency, spinal cord disorders, cephalopathy, and other neurological diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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