The invention relates relates to new substituted quinolines of formula 1wherein R1 is a linear or branched C1-6-alkyl, wherein R1 may optionally be substituted by R3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkl a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O wherein R3 may optionally be substituted further substituted as defined in claim 1 and wherein R2 is selected from the group consisting of halogen, phenyl, a five- or six-membered monocyclic heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O a bicyclic, nine-, ten- or eleven-membered, either aromatic or non-aromatic, but not fully saturated heterocycle comprising one, two, three or four heteroatoms each independently selected from the group consisting of N, S and O wherein R2 may optionally be further substituted as defined in claim 1, and their use in the preparation of medicaments for the treatment of disease such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis.本發明係關於新穎的式1之經取代喹啉,其中R1 為直鏈或分支鏈C1-6烷基,其中R1可視情況經R3取代,R3選自由以下組成之群:3、4、5、6或7員環烷基;5、6或7員包含1、2或3個各自獨立地選自由N、S及O組成之群之雜原子的飽和雜環;及5或6員包含1、2或3個各自獨立地選自由N、S及O組成之群之雜原子的雜芳基;其中R3可視情況如技術方案1中所定義之取代法進一步經取代,且其中R2 選自由以下組成之群:鹵素;苯基;5或6員包含1、2或3個各自獨立地選自由N、S及O組成之群之雜原子的單環雜芳基;9、10或11員包含1、2、3或4個各自獨立地選自由N、S及O組成之群之雜原子的雙環芳族或非芳族但不完全飽和之雜環;其中R2可視情況如技術方案1中所定義進一步經取代,及其在製備供治療諸如哮喘、COPD、過敏性鼻炎、過敏性皮炎及類風濕性關節炎之疾病用之藥劑中的用途。
