Benzodiazepines (INOL) derivatives of carbamate or its salts, as opposed to TRPV4； including the pharmacological components of benzodiazepines, used in the treatment of diseases related to intestinal edema, pulmonary disorders, and cardiovascular diseases Renal dysfunction, osteoarthritis, etc.
CHEUNG MUI,BROOKS CARL,EIDAM HILARY SCHENCK,GOODMAN KRISTA B,HAMMOND MARLYS,HILFIKER MARK A,HOANG TRAM H,PATTERSON JACLYN R,STOY PATRICK,YE GUOSEN
申请号：
CL2013003602
公开号：
CL2013003602A1
申请日:
2013.12.16
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
A combination comprising a compound of Formula (I): or a pharmaceutically acceptable salt thereof； and one or more other therapeutic agents, selected from the group consisting of endothelin receptor antagonists, angiotensin converting enzyme (ACE) inhibitors, angiotension II receptor antagonists, vasopeptidase inhibitors, vasopressin receptor modulators, diuretics, digoxin, beta blocker, aldosterone antagonists, iontropes, NSAIDS, nitric oxide donors, calcium channel modulators, muscarinic antagonists, steroidal anti-inflammatory drugs, bronchodilators, anti-histamines, leukotriene antagonist, HMG-CoA reductase inhibitors, dual non-selective ²-adrenoceptor and ± 1 -adrenoceptor antagonists, type-5 phosphodiesterase inhibitors, and renin inhibitors.COMPUESTOS DERIVADOS DE BENZOIMIDAZOL (INDOL) DE ANALOGOS DE ESPIROCARBAMATO O SUS SALES COMO ANTAGONISTAS DE TRPV4； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, UTIL PARA EL TRATAMIENTO DE ATEROSCLEROSIS, TRASTORNOS RELACIONADOS CON EDEMA INTESTINAL, TRASTORNOS PULMONARES, ENFERMEDAD CARDIOVASCULAR, DISFUNCION RENAL, OSTEOARTRITIS, ENTRE OTRAS.
