Highly flexible penetrating liposomal carrier systems are formulated with enhanced skin penetration properties. These specialized formulations of highly flexible penetrating liposomal delivery systems comprise one or more phospholipids, lysophosphatides and hydrophobic photosensitizer. This new formulations can squeeze liposomal particles through intercellular regions of stratum corneum as intact structures, and, in this way, deliver encapsulated photosensitizer to the epidermis, dermis, hypodermis and surroundings. The penetrating liposomal formulation provides therapeutically effective amounts of the hydrophobic photosensitizer through topical application with better skin penetration thus improving drug targeting and the efficacy of photodynamic therapy (PDT).本發明係關於高彈性穿透性脂質體載劑系統,經調配成具有提高的皮膚穿透特性。這些高彈性穿透性脂質體遞送系統的專用調配物,包括一或多種磷脂、溶血磷脂和疏水性光敏劑。該新穎調配物可壓擠脂質體顆粒,以完整結構通過角質層之細胞間區域,並以此方式遞送包膠過的光敏劑至表皮、真皮、皮下組織和周圍。穿透性脂質體調配物以較佳的皮膚穿透性,經由局部施用提供了治療有效量之疏水性光敏劑,因此改善了光動力療法(PDT)的藥物靶定和效力。
