FARMER, GERARD,SCHEGLMANN, DIETRICH,ALBRECHT, VOLKER,NIFANTIEV, NIKOLAY, E.
申请号：
EP07776843
公开号：
EP2051699A4
申请日:
2007.05.08
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Highly flexible penetrating liposomal carrier systems are formulated with enhanced skin penetration properties. These specialized formulations of highly flexible penetrating liposomal delivery systems comprise one or more phospholipids, lysophosphatides and hydrophobic photosensitizer. This new formulations can squeeze liposomal particles through intercellular regions of stratum corneum as intact structures, and, in this way, deliver encapsulated photosensitizer to the epidermis, dermis, hypodermis and surroundings. The penetrating liposomal formulation provides therapeutically effective amounts of the hydrophobic photosensitizer through topical application with better skin penetration thus improving drug targeting and the efficacy of photodynamic therapy (PDT).
