A method for treating an inflammatory or vascular condition by transdermally regulating inflammation in a target area of the body having an inflammatory or vascular condition by topically applying to the skin of the target area a therapeutically effective amount of at least one anti-VEGF containing compound. A device, which may be comprises a transdermal patch, a bandage, a paint, an atomized spray, for treating an inflammatory or vascular condition is also disclosed. The device is configured to transdermally apply to the skin of the target area a therapeutically effective amount of at least one anti-VEGF containing compound that regulates inflammation in the target area.