In one aspect, a method for generating higher resolution volumetric image data from lower resolution volumetric image data includes receiving volumetric image data of a scanned subject, wherein the volumetric image data includes data representing a periodically moving structure of interest of the scanned subject, and wherein the volumetric image data covers multiple motion cycles of the periodically moving structure of interest. The method further includes estimating inter-image motion between neighboring images of the received volumetric image data. The method further includes registering the received volumetric image data based at least on the estimated inter-image motion. The method further includes generating the higher resolution volumetric image data based on the registered volumetric image data, a super resolution post-processing algorithm, and a point spread function of an imaging system that generated the volumetric image data. The higher resolution volumetric image data has an image resolution that is greater than the lower resolution volumetric image data.
