Johannes Jan Platteeuw,Herman Jan Tijmen Coelingh Bennink
申请号：
US15852187
公开号：
US09987287B2
申请日:
2017.12.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight of 50-1,000 mg and containing at least 0.1 mg of an estetrol component selected from estetrol, estetrol esters and combinations thereof. This solid dosage unit consists of:4-95 wt. % of granules consisting of: 3-80 wt. % of an estetrol component selected from estetrol, estetrol esters and combinations thereof；20-97 wt. % C4-C12 sugar alcohol；0-45 wt. % of one or more other pharmaceutically acceptable ingredients； and5-96 wt. % of one or more pharmaceutically acceptable excipients.The solid dosage units of the present invention are particularly suited for sublingual, buccal or sublabial administration of the estetrol component.
