PLATTEEUW, Johannes Jan,COELINGH BENNINK, Herman Jan Tijmen
申请号：
DK14814804
公开号：
DK3079671T3
申请日:
2014.12.10
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight of 50-1,000 mg and containing at least 0.1 mg of an estetrol component selected from estetrol, estetrol esters and combinations thereof. This solid dosage unit consists of: 4-95 wt. % of granules consisting of: 3-80 wt. % of an estetrol component selected from estetrol, estetrol esters and combinations thereof； 20-97 wt. % C4-C12 sugar alcohol； 0-45 wt. % of one or more other pharmaceutically acceptable ingredients； and 5-96 wt. % of one or more pharmaceutically acceptable excipients. The solid dosage units of the present invention are particularly suited for sublingual, buccal or sublabial administration of the estetrol component.
