László PUSKÁS,Iván KANIZSAI,Thierry PILLOT,Márió GYURIS,András SZABÓ,Ferenc TAKÁCS,László HACKLER
申请号：
MX2017011542
公开号：
MX2017011542A
申请日:
2016.03.07
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
Our invention relates to novel enantiomer derivatives of 8-hydroxyquinoline derivatives with general formula (I) and (II) and the synthesis thereof and pharmaceutically acceptable salts and metal complexes and thereof, and the medicinal and/or pharmaceutical compositions comprising these compounds. The essence of the subject matter of the invention relates to the fact that prior art discloses the biological effect and characteristics only of the racemic products, the novel enantiomer derivatives according to the invention appear in our application for the first. The subject matter of the invention furthermore relates to a novel, stereo selective synthesis for the preparation of the novel enantiomer derivatives according to the invention. The novel medicinal and/or pharmaceutical compositions comprising these enantiomers are suitable for the treatment of the named diseases, and the enenatiomers are used for manufacture of these compositions. These applications for manufacture of the compositions are also the subject matters of the invention. The compounds according to the invention can be used preferably as cytoprotective, neuroprotective, cardioprotective, anxiolytic and antidepressant agent for treatment of neuropsychiatric and neurologic diseases and diseases in connections with transplantations and with ischemia and reperfusion injuries thereof, and inhibition of organ, advantageously skin graft rejection. According to our studies the R-enantiomer has either sole or high biological effect in some cases.La invención se relaciona con derivados de enantioméricos novedosos de derivados de 8-hidroxiquinolina con las fórmulas generalas (I) y (II) y la síntesis de los mismos, y las sales farmacéuticamente aceptables, y los complejos metálicos de los mismos, y las composiciones medicinales y/o farmacéuticas que comprenden estos compuestos. La esencia del tema principal de la invención se relaciona con el hecho de que la técnica anterior describe el efecto biológico y las
