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СПОСОБЫ И СИСТЕМЫ ДЛЯ ВЫЯВЛЕНИЯ И ЛЕЧЕНИЯ ОПУХОЛЕЙ, ВОСПРИИМЧИВЫХ К АНТИПРОГЕСТИНАМ
专利权人:
ИНВАЙВИС ФАРМАСЬЮТИКАЛЗ ИНК. (US)
发明人:
ЖИЛЛЬ Эрар (US)
申请号:
RU2014110504/15
公开号:
RU2014110504A
申请日:
2012.10.04
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method for inhibiting tumor growth, susceptible to growth inhibition by the action of antiprogestins, comprising: a) obtaining a patient tissue sample that is suspected oncogene or cancer b) identification of progesterone receptor positive (PR-positive) cells in said tissue sample c ) determining the extent of progesterone receptor foci in the nucleus of progesterone-positive cells present in said sample of tissue and d) administering an antiprogestin, if the extent of lesions PR in said tissue sample is greater than about 5% of the number of PR-positive kletok.2. A method according to Claim. 1 further comprising determining the extent of lesions in the nuclei PR tissue cells by acting on the fabric against progesterone antibody retseptorov.3. A method according to Claim. 1, wherein the tumor is selected from the group consisting of mammary tumors, brain tumors, meningiomas, prostate tumors, ovarian tumors, endometrial, uterine leiomyoma, lung tumors and tumors matki.4. A method according to Claim. 1, wherein the antiprogestin is selected from the group consisting of onapristone, lonaprizana, mifepristone, PF-02413873, telapristona, lilopristona, ORG2058, and asoprisnila ulipristala.5. A method according to Claim. 1, where the extent of lesions PR is determined by identifying a model progesterone receptor binding to progesterone-positive cells tkani.6. The method of claim. 5, where the binding pattern is selected from the group consisting of diffuse (D), active (A) and the active / diffusion (AD) .7. A method according to claim. 2, wherein for determining the extent of lesions PR is used at least two antitela.8. A method according to claim. 2, wherein the antibodies are selected from the group1. Способ подавления роста опухоли, восприимчивой к ингибированию роста при действии антипрогестинов, включающий:a) получение образца ткани пациента, которая предположительно является онкогенной или раковойb) выявление прогестероновых рецептор-позитивных (PR-позитивных) кл
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