CAI, Chaozhong,MCCOMSEY, David F.,SUI, Zhihua,KANG, Fu An
申请号：
ES13742344
公开号：
ES2627010T3
申请日:
2013.07.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
The compounds of Formula I ** Formula ** wherein R1 is C (1-4) alkylOC (1-4) alkyl, cyclohexyl, or tetrahydropyranyl, wherein said cyclohexyl or tetrahydropyranyl may be optionally substituted with a substituent selected from the group consisting of: OC (1-4) alkyl, OH, CH2CH3, -CN, NH2, NH (CH3), N (CH3) 2, or OCF3； R2 is H, C (S) NHCH2CH (CH3) 2, or C (S) NHCH3； R3 is ** Formula ** H, -CN, C (1-4) alkyl, C (1-4) alkyl AN1A2, C (1-3) alkylC (O) NA1A2, C (3-6) cycloalkyl, oxetan- 3-yl, - (CH2) nPh-Raa, -C (1-4) alkylCO2C (1-4) alkyl, 4,5 dthidro thiazolyl, 4,5 dihydro oxazolyl, thiazolyl, oxazolyl, pyrimidinyl, pyridyl, pyrazyl, furyl , or 3-methyl 1,2,4 oxadiazol-5-yl； wherein said 4.5 dthydro thiazolyl, 4.5 dihydro oxazolyl, thiazolyl, oxazolyl, pyrimidinyl, pyridyl, pyrazyl, and furyl may be optionally substituted with up to two substituents independently selected from Raa. n is 0.1.2, or 3； Ra is H, NA1A2, NHCH2CH2NA1A2, C (1-4) alkyl AN1A2, OC (1-4) to alkyl AN1A2, C (1-6) alkyl, OC (1-6) alkyl, -CN, CH2CH2Ph, -CH2OPh, CH2OC ( O) C (1-4) alkyl, CH2OC (1-4) alkyl, CH2NHBoc, OCH2CH>； = CH2, OCH2CH2CF3, OCH2CH2C (CH3) -2-OH, OCH2CH2OC (1-4) alkyl, -OCH2CH2CN, OPhRaa, * * Formula ** phenyl-Raa, oxazol-2-yl, oxazol-4-yl, isoxazol-5-yl, or thiazol-2-yl； Raa, is H, OC (1-4) alkyl, OCF3, CO2H, Cl, Br, F or CN； Rb is NA1A2； Rc is NA1A2, CH2Ph, CH2CH2Ph, or C (1-4) alkyl； A1 is H, C (1-6) alkyl, PhRaa, C (O) CH3, CH2PhR, or C (1-4) alkylOC (1-4) alkyl； A2 is, C (1-6) alkyl； or A1 and A2 can be taken together with the nitrogen to which they are attached to form a ring selected from the group consisting of: ** Formula ** R4 is CH2Ph, wherein said pH is optionally substituted with up to two selected groups of CF3 , OCF3, and F； R5 is H； or R4 and R5 are taken together with their nitrogen attached to form a fused ring pair selected from the group consisting of: ** Formula ** R6 is CF3, or OCF3； Z1 is CH2 or C>； = O； Z2 is CH2 or Z2 can be C>； = O, provided that Z1 and
