Provided herein are isolated neural stem cells. Also provided are methods for treatment of neurodegenerative diseases using suitable preparations comprising the isolated neural stem cells. In one embodiment, an isolated neural stem cell described herein expresses transcripts for one or more of caudal type homeobox 2 (Cdx2), Nanog homeobox, nestin, octamer-binding transcription factor 4(Oct-4), neurofilament, neurogenin-3 (Ngn3), neomycin-deleted gene (Neo-D), microtubuie-associated protein -2 (MAP-2), CD133, retinoic acid receptor beta (RARJ3), retinoid X receptor alpha (RXRa), retinoid X receptor beta (RXRJ3), cellular retinoic acid binding protein 2 (CRABP-2), cellular retinol binding protein 1 (CRBP-I), retinaldehyde dehydrogenase 2 (RALDH-2) or retinaldehyde dehydrogenase 3 (RALDH-3).La présente invention concerne des cellules souches neurales isolées. L'invention concerne également des méthodes de traitement de maladies neurodégénératives à l'aide de préparations adaptées comprenant les cellules souches neurales isolées.
