Jason Sagert;Nancy E. Stagliano;Patrick Daugherty;James W. West;Kathryn Kamath;Fred Gluck;Paul H. Bessette
发明人:
Nancy E. Stagliano,James W. West,Kathryn Kamath,Paul H. Bessette,Fred Gluck,Jason Sagert,Patrick Daugherty
申请号：
US13455924
公开号：
US08513390B2
申请日:
2012.04.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
