Nancy Elizabeth Stagliano,James William West,Kathryn Kamath,Paul Henry Bessette,Fred Gluck,Jason Gary Sagert,Patrick Daugherty
申请号：
US15140944
公开号：
US20160228546A1
申请日:
2016.04.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
