HOFLACK, JAN MARIE CYRIEL JOZEF,BERTHET, CYRIL,BLOM, PETRA MARCELLA FRANCOISE,VERCOUILLIE, JOHNNY,ROBIC, CAROLINE,CATOEN, SARAH
申请号：
CA3015430
公开号：
CA3015430A1
申请日:
2017.02.28
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to 18-Fluor radiolabeled macrocyclic quinazoline compounds, which are suitable as positron emission tomography (PET) tracers for imaging epidermal growth factor receptors (EGFR), and their use in in vivo diagnosis, preclinical and clinical tumour imaging, patient stratification on the basis of mutational status of EGFR, and assessing tumour response to therapeutic treatments. The present invention also describes precursor compounds and methods of preparing the radiotracers. The invention is relevant to any cancer that is influenced or driven by deregulated EGFR, such as, but not limited to, non-small cell lung cancer (NSCLC), pancreatic, hepatocellular, oesophageal, gastric, colorectal, prostate, cervical, renal, ovarian, breast cancers, head and neck squamous cell carcinoma, and malignant glioma.
