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Solubilized ibuprofen
专利权人:
发明人:
申请号:
EP12190933.7
公开号:
EP2559430A1
申请日:
2006.03.22
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
A process for producing a solubilized ibuprofen, preferably in the form of a granulate, the process comprising the steps of: providing a mixture comprising solid ibuprofen and a first base selected from the group consisting of sodium carbonate and potassium carbonate and mixtures thereof, and reacting the ibuprofen and the first base in essentially dry state. The obtainable granulate and the pharmaceutical compositions and dosage forms that may be produced therefrom are distinguished by their high solubility and rapid disintegration and dissolution in aqueous media, by their good flow properties and compressibility, by rapidly achieving onset of analgesic effect.
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