BOWERS, Peter,MCKNIGHT, Andrew John,KING, David J.,LONDEI, Marco
申请号：
SG11201708061T
公开号：
SG11201708061TA
申请日:
2016.04.15
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the interleukin 36 receptor (IL-36R). The invention provides an IL-36R-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-36R-binding agent to treat a disorder or disease that is responsive to IL-36R inhibition, such as cancer, an infectious disease, or an autoimmune disease.
