Saswati Chatterjee,Laura Jane Smith,Kamehameha Wong
申请号：
US15797868
公开号：
US20180163227A1
申请日:
2017.10.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery.
