MACDONALD, LYNN,STEVENS, SEAN,GURER, CAGAN,MURPHY, ANDREW J.,HOSIAWA, KAROLINA A.
申请号：
MYPI 2012005500
公开号：
MY165287A
申请日:
2011.06.22
申请国别(地区):
MY
年份:
2018
代理人:
摘要：
GENETICALLY MODIFIED MICE ARE PROVIDED THAT EXPRESS HUMAN λ VARIABLE (HVλ) SEQUENCES, INCLUDING MICE THAT EXPRESS HVλ SEQUENCES FROM AN ENDOGENOUS MOUSE λ LIGHT CHAIN LOCUS, MICE THAT EXPRESS HVλ SEQUENCES FROM AN ENDOGENOUS MOUSE λ LIGHT CHAIN LOCUS, AND MICE THAT EXPRESS HVλ SEQUENCES FROM A TRANSGENE OR AN EPISOME WHEREIN THE HVλ SEQUENCE IS LINKED TO A MOUSE CONSTANT SEQUENCE. MICE ARE PROVIDED THAT ARE A SOURCE OF SOMATICALLY MUTATED HUMAN λ VARIABLE SEQUENCES USEFUL FOR MAKING ANTIGEN-BINDING PROTEINS. COMPOSITIONS AND METHODS FOR MAKING ANTIGEN-BINDING PROTEINS THAT COMPRISE HUMAN λ VARIABLE SEQUENCES, INCLUDING HUMAN ANTIBODIES, ARE PROVIDED.
