Imidazo - pyrrolidines nitrogenous Heterocyclic Derivatives, Pharmaceutical compositions containing them and Use thereof for the treatment of HCV infections
MKINNELL ROBERT MURRAY,LONG DANIEL D.,VAN ORDEN LORI JEAN,JIANG LAN,LOO MANDY,SAITO DAISUKE ROLAND,ZIPFEL SHEILA,STANGELAND ERIC L.,LEPACK KASSANDRA,OGAWA GAVIN,HUANG XIAOJUN,ZHANG WEIJIANG
申请号：
ARP110104114
公开号：
AR083757A1
申请日:
2011.11.04
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
1. Requirement 1: a compound (1) with formula characteristics,where: R 1 is selected from C 1-6 alkyl, phenyl, C 3-6 cycloalkyl, heteroaryl, and heterocycle； where C1-6 alkyl is optionally substituted with ORq where it is hydrogen or C1-3 alkyl； R2 is selected from hydrogen and C1-6 alkyl； R3 is selected from hydrogen, C1-6 alkyl, -C (O) O-C1-6 alkyl, -C (O) O3-6 cycloalkyl, C (O) NRaRb, -C (O) C1-6 alkyl , -C (O) C3-6 cycloalkyl, and -S (O) 2 C1-3alkyl； where Ra and Rb are independently hydrogen or C1-6 alkyl； R4 is -C (O) R5 or -S (O) 2R6； R5 is selected from C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, -C (RkRd) NReRf, NRgRh, heteroaryl, heterocycle, -CH2-heteroaryl, and phenyl；donde alquilo C1-6 est opcionalmente sustituido con uno o dos sustituyentes seleccionados en forma independiente entre ORc -S (O) 2alquilo C1-3 -NHC (O) alquilo C1-3 y -NHC (O) O-alquilo C1-3 alcoxi wherein any -C (O) C1-6 alkyl is optionally substituted with -NHC (O) O-C1-3 alkyl, -ORn, NRdRe, or heterocycle, any -C (O) C3-6 cycloalkyl is optionally substituted with one or two C1-3 alkyl, and any -C (O) NH-C1-6 alkyl is optionally substituted with -ORn or C3-6 cycloalkyl； any heteroaryl is optionally substituted with C1-6 alkyl or halo； Rc is independently selected from hydrogen, C1-6 alkyl, and phenyl； Rd is independently hydrogen or C1-6 alkyl； Re is independently hydrogen or C1-6 alkyl； Rf is independently selected from hydrogen, C1-6 alkyl, -C (O) O-C1-6 alkyl, and -C (O) C1-6 alkyl；Rn is independently hydrogen or C1-3 alkyl； Rk is independently selected from hydrogen, C1-6 alkyl, C3-6 cycloalkyl, phenyl, and -CH2ORn； Rg is independently hydrogen or C1-6 alkyl； Rh is independently selected from hydrogen, C1-6 alkyl, C3-6 cycloalkyl, and -S (O) 2 C1-3 alkyl, where C1-6 alkyl is optionally substituted with -ORd； Rj is independently hydrogen or C1-6 alkyl； Rm is independently selected from hydrogen, C1-6 alkyl, -C (O) O-C1-6 alkyl, and -C (O) C1-6 alkyl； R6 is selected from C1-6 alkyl, C3-6
