Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors； (ii) synaptophysin； (iii) zvegf3； (iv) CCR1 receptors； (v) connective tissue growth factor； (vi) alpha 1-smooth muscle actin； (vii) matrix metalloproteinases MMP 2 and MMP9； (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2； (ix) integrins； (x) TFG-β1； (xi) endothelin receptor antagonists； and (xii) collagen synthesis and degradation modulating compounds； (xiii) actin synthesis and degradation modulating compounds； and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.
