Matrix metalloproteinases (MMPs) compositions inactive forms of MMPs (e.g. proMMPs) fragments mutants variants or combinations thereof. A pharmaceutical composition comprises one or more of the above in a pharmaceutical carrier. A composition comprises at least one of: a matrix metalloproteinase (MMP) an inactive MMP or a proenzyme (proMMP) thereof wherein the matrix metalloproteinase (MMPs) inactive MMPs or proMMPs thereof comprise: MMP 1 MMP 2 MMP 3 MMP 7 MMP 8 MMP 9 MMP 10 MMP 11 MMP 12 MMP 13.MMP 14 MMP 15 MMP 16 MMP 17 MMP 18 MMP 19 MMP 20 MMP 21 MMP 23A MMP 23B MMP 24 MMP 25 MMP 26 MMP 27 MMP 28 active fragments mutants variants or any combinations thereof. The uses include isolation of cells in particular stem cells from tissues dissociation of tissues proteins and treatment of a variety of conditions.
