This invention, the medicine substance of water slightly soluble and making the solution contact which at least includes the freezing possible organic solvent of 1 kinds with the low temperature surface, makes the aforementioned solution freeze And the fact that the aforementioned organic solvent is removed is included, it is production method of the medicine particle of micron size or submicron size. It discloses how many execution features of the device which can be used for the execution of method of the particle and this invention which are obtained.本発明は、水難溶性の医薬物質及び少なくとも1種の凍結可能な有機溶媒を含む溶液を低温表面と接触させて、前記溶液を凍結させ;そして前記有機溶媒を除去することを含む、ミクロンサイズ又はサブミクロンサイズの薬物粒子の製造方法である。得られる粒子及び本発明の方法の実施に使用できる装置のいくつかの実施態様も開示する。
