Embodiments of the present invention provide pharmaceutical compositions in unit dosage form that comprise a therapeutically effective amount of levothyroxine sodium an antioxidant in an amount sufficient to stabilize the levothyroxine sodium against oxidation an amount of one or more of a monosaccharide, a disaccharide, and an oligosaccharide sufficient to stabilize the levothyroxine sodium and two or more of a filler, a binder, and a lubricant. Such compositions are free of added alditol and are storage stable
