YANG, JUN MO,양준모,PARK, SEONG BAE,박성배,KANG, JEONG KI,강정기,PARK, MYUNG YOUNG,박명용
申请号：
KR1020100121588
公开号：
KR1020120060031A
申请日:
2010.12.01
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: An injectable liquid composition containing revaprazan or salt thereof in an aqueous medium is provided to ensure excellent stability.CONSTITUTION: An injectable liquid composition has an inclusion complex containing revaprazan or salt thereof or sulfobutyl ether beta-cyclodextrin or 2-hydroxypropyl beta-cyclodextrin. A method for preparing the inclusion complex comprises: a step of dissolving revaprazan or salt thereof with sulfovutyl ether beta-cyclodextrin or 2-hydroxypropyl beta-cyclodextrin in ethanol and a step of drying the solution. The injectable liquid composition additionally contains surfactant, polyethylene glycol-15-hydroxy stearate. The aqueous medium includes distilled water, water for injection, saline solution, glucose solution, or amino acid liquid.COPYRIGHT KIPO 2012본 발명은 수성 매질 중에 레바프라잔 또는 그의 염과 술포부틸 에테르 베타-시클로덱스트린 또는 2-히드록시프로필 베타-시클로덱스트린과의 포접복합체를 포함하는, 주사용 액제 조성물 및 상기 주사용 액제 조성물을 건조시켜 얻어진 주사용 건조 분말을 제공한다.
