Interleukin 15 albumen composition and application thereof农业专利-农业学术服务平台

专利权人:: 上海恒瑞医药有限公司;江蘇恒瑞醫藥股份有限公司;上海恒瑞醫藥有限公司;SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.;JIANGSU HENGRUI MEDICINE CO., LTD.;江苏恒瑞医药股份有限公司

发明人:: QU Xiangdong,屈向东,屈向東,YE, Xin,叶鑫,葉鑫,HU, Oiyue,胡齐悦,胡齊悅,CUI, Dongbing,崔东冰,崔東冰,TAO, Weikang,陶维康,陶維康,ZHANG, Lianshan,张连山,張連山,SUN, Piaoyang,孙飘扬,孫飄揚

摘要：: This application provides a kind of interleukin 15 (IL-15) albumen compositions, the IL-15 albumen composition is made of soluble fusion protein (I) and soluble fusion protein (Π), wherein fusion protein (I) is IL-15 polypeptide or its functional fragment, and fusion protein (Π) is IL-15R α polypeptide or its functional fragment. There are one or more amino acid sites to be mutated into Cys on fusion protein (I) or fusion protein (Π), match to form disulfide bond with the Cys being mutated on corresponding fusion protein (Π) or fusion protein (I) amino acid sites. The IL-15 albumen composition can use what oncotherapy.本申請提供了一種白細胞介素15(IL‑15)蛋白複合物，所述IL‑15蛋白複合物由可溶性融合蛋白(I)和可溶性融合蛋白(Π)組成，其中融合蛋白(I)爲IL‑15多肽或其功能性片段，融合蛋白(Π)爲IL‑15Rα多肽或其功能性片段。融合蛋白(I)或融合蛋白(Π)上具有一個或多個氨基酸位點突變成Cys，與對應的融合蛋白(Π)或融合蛋白(I)氨基酸位點上突變成的Cys配對形成二硫鍵。所述IL‑15蛋白複合物可用於腫瘤治療。