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放射性鹵素標示有機化合物之前驅物化合物的製造方法
专利权人:
LTD.;NIHON MEDI-PHYSICS CO.
发明人:
MASAHITO TOYAMA,外山正人,AKIO HAYASHI,林明希男
申请号:
TW096148317
公开号:
TWI402079B
申请日:
2007.12.17
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
A process for producing a labeled precursor which is useful for production of a radioactive fluorine-labeled amino acid compound is provided. In the reaction step for introducing a leaving group to a mixture of syn-form and anti-form of FACBC, a base is allowed to present in the reaction system to produce a syn-leaving group adduct which is unreactive with the base and is highly stable and an anti-leaving group adduct which can react with the base to form a water-soluble compound. By employing a purification method utilizing such a difference in solubility, the syn-leaving group adduct can be separated selectively. The base may be a linear-chain or branched-chain primary to tertiary alkylamine having 1 to 10 carbon atoms, a nitrogen-containing heterocyclic compound with 2 to 20 carbon atoms, and a nitrogen-containing hetero aromatic compound with 2 to 20 carbon atoms.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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