BUNNETT, NIGEL W.,PORTER, CHRISTOPHER J.H.,COLE, DEREK,HICKS, GARETH,SHIRAI, JUNYA,HIRST, GAVIN
申请号：
CA3009325
公开号：
CA3009325A1
申请日:
2016.12.21
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.
