This specification relates generally to the compound with chemical formula (I): and its pharmaceutically acceptable salt, wherein Q, R1, R2, R3, R4 and R5 have any one of meaning as defined herein. This specification further relates to such compound and its salt to treat or prevent the purposes that the kinase mediated disease of ATM includes cancer. This specification is further to the compound of imidazo [4,5-c] quinoline-2-ketone compound and its crystal form of pharmaceutically acceptable salt； Pharmaceutical composition comprising such compound and salt； Kit comprising such compound and salt； The method for producing such compound and salt； Producing intermediate useful in such compound and salt； And be related to include using the kinase mediated disease of such compound and salts for treating ATM cancer method.本說明書總體上涉及具有化學式(I)的化合物：及其藥學上可接受的鹽，其中Q、R1、R2、R3、R4和R5具有本文所定義的含義中的任一種。本說明書還涉及此類化合物及其鹽用以治療或預防ATM激酶介導的疾病包括癌症的用途。本說明書進一步涉及咪唑并[4,5‑c]喹啉‑2‑酮化合物的化合物及其藥學上可接受的鹽的晶體形式；包含此類化合物和鹽的藥物組合物；包含此類化合物和鹽的試劑盒；生産此類化合物和鹽的方法；在生産此類化合物和鹽中有用的中間體；並且涉及使用此類化合物和鹽治療ATM激酶介導的疾病包括癌症的方法。
