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VACCINS À VIRUS VARICELLE-ZOSTER INACTIVÉ, LEURS PROCÉDÉS DE PRODUCTION ET LEURS UTILISATIONS
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
EP18160689.8
公开号:
EP3363894A1
申请日:
2011.08.04
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the inactivated VZV induces an immune response against VZV when administered to a patient. In embodiments of the compositions described herein, the VZV is inactivated with gamma radiation. The invention also provides a method of preparing an inactivated VZV vaccine, the method comprising gamma irradiating a sample comprising a VZV using from about 5 kGy to about 50 kGy of gamma radiation. Also provided by the invention herein is a method of treatment of or immunization against HZ or other disease associated with the reactivation of VZV, the method comprising administering to a subject a vaccine or pharmaceutical composition comprising a therapeutically effective amount of an inactivated VZV and a pharmaceutically acceptable carrier, wherein the VZV is inactivated by gamma irradiation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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