1. The transdermal delivery device comprising:a support having a first surface and a second surfacea plurality of microneedles extending outwardly from the second support surface, wherein at least one microneedle comprising a base, a tip and an outer surfacepassage comprisingan opening extending between the first support surface and the second support surfacechannel located on the outer surface of at least one microneedle, the channel at the base is combined with at least a portion of the holes to form a compound which can pass through a substance, the compound is formed in the plane of the second surface at the base of the microneedle.2. The transdermal delivery device of claim 1, wherein the compound has the sectional area greater than or equal to about 100 microns2.3. The transdermal delivery device of claim 1, wherein the compound having at least one microneedle, when combined, have a cross-sectional area greater than or equal to about 300 microns2.4. The transdermal delivery device of claim 1, wherein the channel has a cross-sectional area near the base of the microneedle, which is less than or equal to about 25% of the total area of the base.5. The transdermal delivery device of claim 1, wherein the channel has a cross-sectional area near the base of the microneedle, which is less than or equal to about 0.5% of the total area of the base.6. The transdermal delivery device of claim 1, wherein the at least one microneedle having at least two channels, the total sectional area of the channel near the base of the microneedle is less than or equal to about 40% of the total area of the base.7. The transdermal delivery device of claim 1, wherein the microneedle tip has a radius less than or equal to about 1 micron.8. The transdermal delivery device of claim 1, wherein the microneedle has a conical shape near the tip of the microneedle.9. The transdermal delivery device of claim 1, wherein the channel forms a non-linear way on the outer surface of the micronee
