BHINDER TEJINDER KAUR,LEWIS ALAN PETER,PEPYS MARK BRIAN,FORD SUSANNAH KAREN,GERMASCHEWSKI VOLKER
申请号：
NZ60176311
公开号：
NZ601763A
申请日:
2011.03.01
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Discloses an antigen binding protein which binds to SAP and comprising CDR&rsquos CDR H1: TYNMH CDR H2: YIYPGDGNANYNQQFKG CDR H3: GDFDYDGGYYFDS CDR L1: RASENIYSYLA CDR L2: NAKTLAE CDR L3: QHHYGAPLT Wherein the CDR regions may contain substituted amino acids determined by CDR canonical structure cluster analysis, which results in a variant of the binding protein. Further discloses the use of the antigen binding protein for use in treating or preventing a disease associated with amyloid deposition.
