TONER, JOHN K.,约翰 K 透纳,約翰 K 透納,BURKE, SANDRA E.,山卓E. 布克,山卓E. 布克,CROMACK, KEITH R.,凯斯R. 克罗马克,凱斯R. 克羅馬克
申请号：
TW095109967
公开号：
TWI455713B
申请日:
2006.03.22
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery-balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.本發明揭示含有Zotarolimus之系統及組合物,該等系統及組合物較雷帕黴素及紫杉醇系統更安全、更有效且會造成較少之炎症。本發明揭示含有能夠包含或支持一醫藥上可接受之載劑或賦形劑之支持結構的醫藥裝置,該載劑或賦形劑可包含一或多種治療劑或物質,其中該載劑在其表面上具有一塗層,且該塗層含有治療化合物,包括(例如)藥物。適用於本發明之醫藥裝置的支持結構包括冠狀動脈支架、周邊血管支架、導管、動靜脈移植物、旁路移植物、以及用於脈管系統之藥物遞送球囊。此等組合物及系統可與其他藥物聯合使用,其他藥物包括抗增殖劑、抗血小板劑、消炎劑、抗血栓形成劑、細胞毒性藥物、可抑制細胞因子或趨化因子結合之藥劑、細胞去分化抑制劑、抗血脂劑、基質金屬蛋白酶抑制劑、細胞生長抑制劑、或此等與其他藥物之組合。
