Combined antagonists against IL-5/IL-5R and either IL-4/IL-4R or IL-13/IL-13R

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专利权人:

argenx BVBA

发明人:

BLANCHETOT, Christophe,GODAR, Marie,LAMBRECHT, Bart

申请号：

AU2019221627

公开号：

AU2019221627A1

申请日:

2019.02.15

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention relates to combination therapies and to their use in the treatment of chronic airway disease, particularly use in the treatment of asthma. The combination therapies comprise (i) an antagonist of IL-5:IL-5R and (ii) an antagonist of IL-4:IL-4R and/or an antagonist of IL-13:IL-13R. The present invention also provides bispecific antibodies comprising an antigen binding domain that binds to IL-4Rα and an antigen binding domain that binds to IL-5. The bispecific antibodies may be used for the treatment of chronic airway disease, particularly asthma.

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