Novel imidazolyl pyrimidine derivatives preparation method thereof and pharmaceutical composition for use in preventing or treating cancer containing the same as an active ingredient
The present invention relates to a novel imidazolium pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer containing the same as an active ingredient. The imidazolium pyrimidine derivatives, optical isomers thereof or pharmaceutically acceptable salts thereof according to the present invention are useful not only for an activity of a Wee1 kinase, but also has an excellent effect in inhibiting cell proliferation of liver cancer cell line such that the present invention can be usefully used as a pharmaceutical composition for preventing or treating Wee1 kinase related diseases such as liver cancer preferably, and solid cancer such as liver cancer, lung cancer, colorectal cancer, stomach cancer, breast cancer, colon cancer, bone cancer, pancreatic cancer, head or neck cancer, uterine cancer, ovarian cancer, rectal cancer, esophageal cancer, small bowel cancer, cancer nearby an anus, fallopian tube cancer, endometrial carcinoma, cervical carcinoma, vaginal carcinoma, vulvar carcinoma, prostate cancer, bladder cancer, renal cancer, ureter cancer, renal cell carcinoma, renal pelvic carcinoma, central nervous system tumor cancer, and the like.본 발명은 신규한 이미다졸일 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 이미다졸일 피리미딘 유도체, 이의 광학 이성질체 또는 이의 약학적으로 허용 가능한 염은 Wee1 키나아제의 활성뿐만 아니라, 간암 세포주의 세포증식을 억제하는 효과가 우수하여, Wee1 키나아제 관련 질환, 예를 들어, 간암, 폐암, 대장암, 위암, 유방암, 결장암, 골암, 췌장암, 두부 또는 경부암, 자궁암, 난소암, 직장암, 식도암, 소장암, 항문부근암, 나팔관암종, 자궁내막암종, 자궁경부암종, 질암종, 음문암종, 전립선암, 방광암, 신장암, 수뇨관암, 신장세포암종, 신장골반암종, 중추신경계 종양간암 등과 같은 고형암, 바람직하게 간암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
