PROBLEM TO BE SOLVED: To design and synthesize β strand mimetics using structural characteristics of cyclopropane and provide a new (pro)renin receptor ligand, and also provide a new (pro)renin receptor inhibitor that is excellent in solubility, stability and others and has a high potential of clinical application.SOLUTION: A prorenin receptor ligand is represented by formula (1) and the like (X1 is an alkyl group or the like X2 is an alkyl group having a nitrogen-containing basic substituent, or the like X3 and X4 represent H or form a carbonyl group (C=O) together with C bound to each of them R1 and R2 independently represent H, an alkyl or the like).SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】シクロプロパンの構造的特徴を利用したβストランドミメティックを設計、合成し、新たな(プロ)レニン受容体リガンドの提供。溶解性・安定性などに優れ、臨床応用の可能性が高い、新たな(プロ)レニン受容体の阻害剤の提供。【解決手段】式(1)等で示されるプロレニン受容体リガンド。(X1はアルキル基等;X2は含窒素塩基性置換基を有するアルキル基等;X3及びX4はH又はそれぞれが結合するCと共にカルボニル基(C=O);R1及びR2は各々独立にH、アルキル等)【選択図】なし
