PROCEDE DE PRODUCTION DE CELLULES SOUCHES/PRECURSEURS HEPATIQUES A PARTIR DE CELLULES HEPATIQUES MATURES A L'AIDE D'UN COMPOSE DE FAIBLE POIDS MOLECULAIRE
The present invention provides a method for producing hepatic stem/precursor cells from hepatic cells of a mammal, the method comprising bringing a TGFß-receptor inhibitor, and optionally a GSK3 inhibitor and/or a ROCK inhibitor, into contact with the hepatic cells in vitro.