Fernando Pedro Cossío Mora;Aizpea Zubia Olascoaga;Eider Ion San Sebastián Larzabal;María del Carmen Masdeu Margalef;Yosu Vara Salazar;Dorleta Otaegui Ansa;Eneko Aldaba Arévalo
发明人:
Fernando Pedro Cossío Mora,Aizpea Zubia Olascoaga,Yosu Vara Salazar,Eider Ion San Sebastián Larzabal,Dorleta Otaegui Ansa,María del Carmen Masdeu Margalef,Eneko Aldaba Arévalo
申请号：
US13499839
公开号：
US20120196885A1
申请日:
2010.10.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I):wherein:R1 and R2 represent, independently, an optionally substituted C6-C10 aryl radical or an optionally substituted heteroaryl radical；A and M represent, independently, a methylene group or a single bond, in which case the adjacent aromatic ring would be attached directly to the amide group；the Y═Z group represents together and indistinctly an oxygen atom, a sulfur atom, a cis-vinylidene group, an imino group, or a methine group with a sp2-hybridized carbon atom；X represents indistinctly a methine group, a cis-vinylidene group or a nitrogen atom； andW represents a hydroxyl group, an optionally substituted C1-C6 alkyl group, an optionally substituted heteroaryl group or an optionally substituted C6-C10 aryl group；or a salt, solvate or prodrug thereof,as well as to the process for their preparation and the use thereof for the treatment of cancer.
