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MULTI-RESPONSIVE TARGETING DRUG DELIVERY SYSTEMS FOR CONTROLLED-RELEASE PHARMACEUTICAL FORMULATION
专利权人:
George KORDAS
发明人:
George KORDAS,Eleni EFTHIMIADOU
申请号:
US15035855
公开号:
US20160263221A1
申请日:
2014.11.21
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention proposes the development of technology in the domain of targeted therapy and local drug delivery to the affected area of the tumor. The invention relates to surface modification nano-/micro-containers (spheres of organic and inorganic polymers), which are sensitive to acidic environment, elevated temperature (T˜41-43° C.), redox potential as well as the application of external applied magnetic field. These nano-/micro-containers are made suitable to be able to carry drugs, such as antibiotics, anti-cancer, cytostatic and antimicrobials and their release will be carried to the patient tissue due to the prevailing conditions. The composition of nano-/miocro-containers based on organic and inorganic polymers which exhibit sensitivity to the aforementioned conditions. The adjustment is carried out through the surface with aminosilanes or amino acids as ligands or small molecules such maleamide molecules which can undergo nucleophilic addition and further binding of targeting molecule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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