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CHITOSAN DENTAL SURGICAL MEMBRANE AND METHOD OF MAKING
专利权人:
发明人:
Joseph F. Bristow,Bruno R. Stockinger
申请号:
US14359254
公开号:
US20140314825A1
申请日:
2012.11.20
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A porous, resorbable and flexible dental surgical membrane (16) is made from chitosan having a molecular weight of at least 400,000 daltons and has a thickness of from about 100 microns to about 0.5 mm. The membrane is easily insertable over a bone graft material site to confine the bone graft material (14) while allowing access to it of blood and oxygen. The high molecular weight of the chitosan may be chosen so that the membrane will not dissolve or resorb in a human mouth for a protracted period, e.g., from about 12 to about 16 weeks. The membrane is made by dissolving medical grade chitosan in aqueous acetic acid, dispersing fine silica particles into the solution to form a slurry, depositing a film of the slurry on a support surface, evaporating liquid from the slurry sufficiently to form a coherent chitosan membrane having silica particles dispersed therein, and then dissolving the silica particles with a sodium hydroxide solution followed by a water wash to form the porous chitosan membrane.
来源网站:
中国工程科技知识中心
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