Use of microvesicles (MV) to prepare medicaments with adjuvant activity in the treatment of diabetes by endothelial cell transplantation, especially islet transplantation, and related methods

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专利权人:

フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング

发明人:

ヴィンセンツォ・カンタルッピ,マリア・キアラ・アミルデ・デレジブス,ジョヴァンニ・カムッシ

申请号：

JP2010529508

公开号：

JP5719171B2

申请日:

2007.10.15

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The invention relates to the use of microvesicles derived from cells of the endothelial cell lineage, preferably from endothelial progenitor cells, as an adjuvant agent in endothelial cell-pancreatic islet transplantation, particularly in the treatment of type I or type II diabetes by pancreatic islet transplantation. The adjuvant effect of the microvesicles consists in the improvement of survival and functionality of the transplanted islets. The adjuvant effect of the microvesicles is maintained even when the recipient is subjected to rapamycin-based immunosuppression.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/