Arthur M. DEBOECK,Francis VANDERBIST,Antonio SERENO
申请号：
US13506390
公开号：
US20130330404A1
申请日:
2012.04.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
An oral tramadol pharmaceutical composition for once daily administration, containing an effective amount of tramadol or a pharmaceutically-acceptable salt thereof, providing in vivo, a time of tramadol peak plasma concentration (Tmax) greater than 10 hours and a peak tramadol plasma concentration (Cmax) which is less than three times a plasma concentration obtained 24 hours after administration (C24h) of a single dose of the composition.
