DAI, WEI-GUO,DONG, LIANG-CHANG,CHOI, TAE-HONG,HWANG, SUNG JOO,KIM, JAE, HYUN,LEE, DONG, HO
申请号：
NZ59232509
公开号：
NZ592325A
申请日:
2009.10.23
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein is a pharmaceutical composition, comprising acetaminophen (paracetamol) and a complex tramadol material, that exhibits coordinated sustained release upon dissolution resulting in coordinated accumulative release of tramadol and accumulative release of acetaminophen over time, wherein the complex tramadol material is complexed using carrageenan. Also disclosed are methods of making a dose form of the pharmaceutical composition as disclosed above and use of such composition in the treatment of pain.
