ШЕЙ Лонни Д. (US),ЯП Джонатан Вун Тек (US),МИЛЛЕР Стивен Д. (US),МАККАРТИ Деррик (US),ГЕТТЗ Даниэль Р. (US)
申请号：
RU2015101758
公开号：
RU2015101758A
申请日:
2013.06.21
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A composition comprising: an antigen associated with a carrier particle with a negative zeta potential. 2. A composition according to claim 1, characterized in that the zeta potential of the particle is from about -100 mV to about 0 mV. 3. A composition according to claim 2, characterized in that the zeta potential of the particle is from about -50 mV to about -40 mV. 4. The composition of claim 1, wherein the particle is a copolymer having a molar ratio of from about 80:20 to about 100: 0.5. A composition according to claim 1, characterized in that the particle is a polystyrene particle, a carboxylated polystyrene particle or a copolymer particle of lactic and glycolic acids. A composition according to claim 1, characterized in that the particle has a diameter of from about 0.1 microns to about 10 microns. A composition according to claim 6, characterized in that the particle has a diameter of from about 0.3 microns to about 5 microns. A composition according to claim 7, characterized in that the particle has a diameter of from about 0.5 microns to about 3 microns. The composition of claim 8, wherein the particle has a diameter of from about 0.5 microns to about 1 microns. The composition of claim 9, wherein the particle has a diameter of about 0.5 microns. A composition according to claim 1, characterized in that the antigen is bound to the surface of the carrier particle. A composition according to claim 1, characterized in that the antigen is encapsulated in a carrier particle. The composition of claim 1, wherein said antigen comprises an autoimmune antigen, an antigen expressed on a tissue to be transplanted to a subject, or an allergen. The composition of claim 13, wherein said antigen comprises at least a portion of a protein selected from the group1. Композиция, содержащая: антиген, связанный с несущей частицей с отрицательным дзета-потенциалом.2. Композиция по п. 1, отличающаяся тем, что дзета-потенциал частицы составляет от приблизительно -100 мВ до при
