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МОЛЕКУЛА, СОДЕРЖАЩАЯ SPR0096 И SPR2021
专利权人:
НОВАРТИС АГ (CH)
发明人:
КОСТАНТИНО Паоло (IT),РОМАНО Мария Розария (IT)
申请号:
RU2014123021/10
公开号:
RU2014123021A
申请日:
2012.11.07
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A conjugate comprising an antigen and a molecule carrier, wherein the carrier molecule comprises an antigen and an antigen spr0096 spr2021.2. The conjugate of claim 1, wherein the antigen spr0096 comprises an amino acid sequence having 50% or more identity with SEQ ID NO:. 1 or SEQ ID NO: 2.3. The conjugate of claim 1 or 2, wherein the antigen spr2021 comprises an amino acid sequence having 50% or more identity with SEQ ID NO:. 3.4. The conjugate according to Claim. 1, wherein the carrier molecule comprises an antigen and an antigen spr0096 spr2021 as a single polypeptide tsepi.5. The conjugate of claim 4, wherein the polypeptide chain has the formula NH-A - {- XL -} - B-COOH, where A is an optional N-terminal amino acid sequence. B is an optional C-terminal amino acid sequence n represents an integer of 2 or more (e.g., 2, 3, 4, 5, 6, etc.) each X is an amino acid sequence spr0096 spr2021 antigen or antigen, wherein at least one X is an antigen spr0096 and at least one X is an antigen spr2021 and L is an optional linker amino acid posledovatelnost.6. The conjugate of claim. 5 where n is equal to 2.7. The conjugate of claim. 6 where Χpredstavlyaet spr0096 an antigen and an antigen Hpredstavlyaet spr2021.8. The conjugate of claim. 7, where the polypeptide chain comprises an amino acid sequence having 50% or more identity (e.g. 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93 %, 94%, 95%, 96%, 97%, 98%, 99%, 99.5% or more) to SEQ ID NO: 9, in particular the amino acid sequence of SEQ ID NO: 9.9. The conjugate according to Claim. 1, where the antigen is a saharid.10. The conjugate of claim. 9, wherein the saccharide is a capsular saccharide from N. meningitidis, or capsular glucan1. Конъюгат, содержащий антиген и молекулу носителя, где молекула носителя содержит антиген spr0096 и антиген spr2021.2. Конъюгат по п. 1, где антиген spr0096 содержит аминокислотную последовательность, имеющую 50% или более идентичность с SEQ ID NO: 1 или SEQ ID NO: 2.3. Конъюгат по п. 1 ил
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