The present invention provides a system for real-time pain detection, which comprises a means for acquiring biomedical signals relating to pain in a subject in need thereof, a computing means for transforming the acquired biomedical signals during a given period of time into the signal data for measurement of pain, analyzing the data to divide into two or more models, including at least a pain model which is defined by the data showing a peak-shaped profile and a non-pain model which is defined by the data showing a flat profile, whereby the pain status of the subject is measured based on the results of the analysis, a process means for generating an index of pain using the results of the analysis depending on the subject's demands or sensation, and a display showing the pain status of the subject.
