PROBLEM TO BE SOLVED: To provide a rapidly disintegrating tablet in oral cavity which contains drug having unpleasant sensory characteristic, in which unpleasant sensory characteristic felt in taking the tablet is reduced, and delayed release does not occur even when gastric pH of a patient is high.SOLUTION: There is provided a rapidly disintegrating tablet in oral cavity which contains drug-containing granules having: coating containing (A) water-insoluble cellulose ether (B) water-insoluble acrylic acid-based polymer (C) anionic surfactant and (D) nonionic surfactant, and total weight of (A) and (B) is 0.25 pt.wt. or more with respect to 1 pt.wt. of grains containing drug having unpleasant sensory characteristic, outside grains containing drug having unpleasant sensory characteristic.COPYRIGHT: (C)2014,JPO&INPIT【課題】不快な官能的性質を有する薬物を含有する口腔内速崩壊性錠剤であって、服用時に感じる不快な官能的性質を低減し、且つ、患者の胃内pHが高い場合でも、放出遅延を生じない口腔内速崩壊性錠剤を提供すること。【解決手段】不快な官能的性質を有する薬物を含有する粒子の外側に、(A)水不溶性セルロースエーテル、(B)水不溶性アクリル酸系ポリマー、(C)陰イオン性界面活性剤及び(D)非イオン性界面活性剤を含有する皮膜を有する薬物含有顆粒であり、(A)と(B)の合計重量が、不快な官能的性質を有する薬物を含有する粒子1重量部に対し、0.25重量部以上であることを特徴とする薬物含有顆粒、を含有する口腔内速崩壊性錠剤。【選択図】図1
