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IMPROVED MONOCLONAL ANTI-VEGR-2 ANTIBODIES
专利权人:
БЕЙДЗИН ДУНФАН БАЙОТЕК КО., ЛТД.
发明人:
Бай, И,Гу, Сянго,И,Сянго
申请号:
EA201991788
公开号:
EA201991788A1
申请日:
2018.02.14
申请国别(地区):
EA
年份:
2020
代理人:
摘要:
The application belongs to the technical field of biomedicines and provides an improved anti-Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) monoclonal antibody and an application thereof. By a computer-aided simulation design, a novel phage antibody library is designed, and an improved anti-VEGFR-2 monoclonal antibody is obtained after multiple rounds of screening. Both affinity and biological activity of the antibody are higher than those of an original antibody. The antibody is capable of effectively inhibiting combination of VEGFR-2 and a ligand Vascular Endothelial Growth Factor (VEGF) thereof in vitro, and may be used in treating a tumor and a disease caused by angiogenesis such as macular degeneration.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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