The present disclosure describes ultrasound imaging systems and methods configured to identify and remove image artefacts from ultrasound image frames by applying a neural network to the frames. Systems may include an ultrasound transducer configured to acquire echo signals responsive to ultrasound pulses transmitted toward a target region. One or more processors communicatively coupled with the ultrasound transducer may be configured to generate an image frame from the ultrasound echoes and apply a neural network to the image frame. The neural network determines whether an artefact is present in the image frame, and identifies the type of artefact detected. The processors can also generate an indicator conveying the presence of the artefact, which can be displayed on a user interface. The processors can further generate an instruction for adjusting the ultrasound transducer based on the presence and type of artefact present within the image frame.